| Blue Knuckles | Specially designed for devastating uppercuts. | Alucard | ATK +11 | Chapter 1 |
| Brass Knuckles | Metal weapon that adds sting to your punches. | Soma | ATK +7 | Chapter 5 |
| Cestus | Hard knuckle guards worn by ancient boxers. | Soma | ATK +11 | Shop, Chapter 5 |
| Fist of Tulkas | Blessed by Tulkas the Valar. | Alucard | ATK +40 | Chapter 6 - Hard |
| Jewel Knuckles | Jewel reinforced knuckles. | Alucard | ATK +14 | Chapter 6 |
| Kaiser Knuckle | Imbues knuckles with divine rage. | Alucard, Soma | ATK +25, HP +3 | Chapter 2 - Hard, Chapter 3 - Hard, Chapter 4 - Hard |
| Knuckle Dusters | Iron-studded brass knuckles. | Alucard | ATK +3 | Chapter 4 - Hard, Chapter 6 - Hard |
| Mach Punch | Enables punches to be thrown at the speed of sound. | Soma | ATK +10, HP +3 | Chapter 6 - Hard |
| Whip Knuckle | Enables quick, whip-like punches. | Soma | ATK +30 | Chapter 5 - Hard |
